Effect of Statins on Skeletal Muscle Function
نویسندگان
چکیده
منابع مشابه
Effect of statins on skeletal muscle function.
BACKGROUND Many clinicians believe that statins cause muscle pain, but this has not been observed in clinical trials, and the effect of statins on muscle performance has not been carefully studied. METHODS AND RESULTS The Effect of Statins on Skeletal Muscle Function and Performance (STOMP) study assessed symptoms and measured creatine kinase, exercise capacity, and muscle strength before and...
متن کاملThe effect of statins on skeletal muscle function: the STOMP trial.
1 1 Di Di Div vision o of f f Ca Ca Card rd rdio iolo lo logy gy gy, , He He H nr nr nry y y Lo Lo Low w w He He Hear ar rt t t Ce Ce C nt n e er er, Ha a art rt rtfo fo ford rd rd H H Ho o ospi pi pita ta t l, l, l, H H Hartf tf for or ord, d, d C C CT; T; 2 2 Un Un Univ iv iver r ersi s s ty of o o M M Ma a assa ach ch huset et tts ts, , Am Amhe he h r rs st, , MA A; A; 3 Un n niv ver er rsi ...
متن کاملEffect of statins on skeletal muscle: exercise, myopathy, and muscle outcomes.
Statins are effective in reducing low-density lipoprotein cholesterol and cardiac events but can produce muscle side effects. We have hypothesized that statin-related muscle complaints are exacerbated by exercise and influenced by factors including mitochondrial dysfunction, membrane disruption, and/or calcium handling. The interaction between statins, exercise, and muscle symptoms may be more ...
متن کاملEffect of isolated AMP deaminase deficiency on skeletal muscle function☆
Mutation of the AMP deaminase 1 (AMPD1) gene, the predominate AMPD gene expressed in skeletal muscle, is one of the most common inherited defects in the Caucasian population; 2-3% of individuals in this ethnic group are homozygous for defects in the AMPD1 gene. Several studies of human subjects have reported variable results with some studies suggesting this gene defect may cause symptoms of a ...
متن کاملEffect of skeletal muscle demand on cardiovascular function.
Cardiac output is directed primarily to skeletal muscle during exercise. Recent investigations have examined how different groups of skeletal muscle compete for the cardiac output during exercise. To date, there is a lack of consistent findings on a blood flow steal effect of arm versus leg exercise, although the majority of data suggest that leg blood flow is not compromised when arm exercise ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 2013
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.112.136101